Sammy Kipketer of Kenya won the men's race for the third consecutive year.
Drossin seized control of the race by running the first mile in 4:45, then covered the second uphill mile in a blazing 4:47.
The 29-year-old Drossin eclipsed the previous record in the 5,000 meter road race of 14:57, set by Paula Radcliffe in September in London. Drossin became the first American woman to set a 5,000-meter record since PattiSue Plumer ran 15:31 at Carlsbad in 1986.
Tirunesh Dibaba, a 17-year-old from Ethiopia, was second in 15:19 and Werknesh Kidane of Ethiopia was third in 15:20. Ireland's Sonia O'Sullivan, a 2000 Olympic silver medalist, finished seventh.
Kipketer won in 13:17, slower than the 13-minute world-record times he ran the previous two years.
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